Sperm DNA damage assessment: a test whose time has come.

نویسندگان

  • Ashok Agarwal
  • Shyam S R Allamaneni
چکیده

Multiple techniques have been developed to measure the amount of sperm DNA damage in an effort to identify more objective parameters for evaluation of infertile men. We now have evidence to support that integrity of sperm DNA influences a couple's fertility and helps predict the chances of pregnancy and its successful outcome. The available tests of sperm DNA damage require additional large-scale clinical trials before their integration into routine clinical practice.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-65: Nitrosative Stress, Lipid and Carbonyl Groups Peroxidations in Long Time-Induced Varicocele; Association with Sperms DNA Damage in Rats

Background: The pathophysiology of the varicocele has received considerable study, both in humans and in animal models. The sperm DNA damage and related oxidative stress have been identified as significant cause of male infertility. Present study was designed to evaluate the testicular nitric oxide (NO) generation, lipid and carbonyl groups (CGs) peroxidation and to analyze related sperm DNA da...

متن کامل

P-7: Sperm DNA Assessment as A Tool for Partial Resolver of The Unexplained Infertility Problem

Background: To establish importance of sperm DNA assessment in resolving the unexplained infertility problem. Materials and Methods: This article is based on the careful observation of texts and papers from 2000-2014 about the DNA damage assessment as a significant parameter of sperm function test. Results: Acidic Aniline blue, Sperm Chromatin Dispersion test(SCD), Malondialdehyde concentration...

متن کامل

Etiology and Evaluation of Sperm Chromatin Anomalies

Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomes and infertile men possess substantially amount of sperm with chromatin anomalies than fertile men. Routine semen analysis evaluates parameters such as sperm motility and morphology, but does not examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclear chromatin struc...

متن کامل

I-37: Genome Instability and DNA Damage in Male Somatic and Germ Cells Expressed as Chromosomal Microdeletion and Aneuploidy Is A Major Cause of Male Infertility

Background: Sperm chromatin insufficiencies leading to low sperm count and quality, infertility and transmission of chromosomal microdeletion and aneuploidies to next generations can be due to exposure to environmental pollutions, chemicals and natural or manmade ionizing radiation. In this project which has continued for more than 10 years and is unique in many technical aspects in Iran and in...

متن کامل

P-48: Evaluation of The Effectiveness of Zinc and Alpha-Tocopherol on Total Sperm Count, Apoptosis, DNA Damage, DNA Breakage and Viability of Sperms Under Cell Phone Radiation and Comparison Between These Protocols

Background There has been a growing claim about the stress induced by the modern life and especially by cell phones. It may have detrimental effect on sperms. We examined the relationship of stress caused by cell phone radiation and the effect of Zinc and Alpha-tocopherol on the sperms and its chromatin in this condition. MaterialsAndMethods Fresh semen has been collected from 20 young men. Eac...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Fertility and sterility

دوره 84 4  شماره 

صفحات  -

تاریخ انتشار 2005